VERTEBROBAZILAR YETISHMOVCHILIKNI TURLI ETIOPATOGENETIK SHAKLLARINING EPIGENETIK O’ZIGA XOS XUSUSIYATLARI
- Авторы:Xamidov Abdulaxad Abdisattor o’g’li. Saidvaliev Farrux Saidakromovich
- Дата публикации:September 15, 2025
- Тип:Статья
- DOI: 10.64156/mju.8284 Скопировано
- Том / № Выпуска:Том 1 №4 номер
Аннотация
Annatatsiya.
Tadqiqot maqsadi: Mazkur tadqiqotning asosiy maqsadi — VBYning turli etiopatogenetik shakllarida epigenetik xususiyatlarni aniqlash hamda differensial diagnostik mezonlarni ishlab chiqishdir.
Tadqiqod materiali va metodi: So‘nggi 10 yil ichida PubMed, Scopus va Web of Science bazalarida chop etilgan maqolalar. Adabiyotlar tanlovi — PRISMA talablariga muvofiq, 2015–2025 yillarda chop etilgan maqolalar saralandi.
Xulosa: Epigenetik markerlar: miR-155 — yallig‘lanish va ateroskleroz markeridir, og‘ir kechish bilan bog‘liq. miR-126 — angioprotektiv marker, tiklanish va yaxshi prognoz bilan bog‘liq. miR-221 — VSMC proliferatsiyasi va ateroskleroz o‘sishini kuchaytiruvchi marker.
Kalit so’zlar: Vertebrobazilyar yetishmovchilik (VBY), Aterosklerotik, Migren, Qon tomir anomaliyalari.
Аннотация.
Цель исследования: Основной целью данного исследования является выявление эпигенетических особенностей при различных этиопатогенетических формах ВБН и разработка дифференциально-диагностических критериев.
Материал и методы исследования: Статьи, опубликованные в базах данных PubMed, Scopus и Web of Science за последние 10 лет. Отбор литературы — в соответствии с требованиями PRISMA были отобраны статьи, опубликованные в 2015–2025 годах.
Заключение: Эпигенетические маркеры: miR-155 — маркер воспаления и атеросклероза, ассоциированный с тяжелым течением. miR-126 — ангиопротективный маркер, ассоциированный с выздоровлением и хорошим прогнозом. miR-221 — маркер, усиливающий пролиферацию гладкомышечных клеток сосудов и рост бляшек.
Ключевые слова: Вертебробазилярная недостаточность (ВБН), атеросклероз, мигрень, сосудистые аномалии.
Abstract.
Aim of the study: The main aim of this study is to identify epigenetic features in various etiopathogenetic forms of VBI and to develop differential diagnostic criteria.
Material and methods of the study: Articles published in PubMed, Scopus, and Web of Science databases in the last 10 years. Literature selection — articles published in 2015–2025 were selected in accordance with PRISMA requirements.
Conclusion: Epigenetic markers: miR-155 is a marker of inflammation and atherosclerosis associated with severe disease. miR-126 is an angioprotective marker associated with recovery and good prognosis. miR-221 is a marker that enhances vascular smooth muscle cell proliferation and plaque growth.
Key words: Vertebrobasilar insufficiency (VBI), atherosclerosis, migraine, vascular anomalies.
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